Propargylamine → HCID 22557994, compound

HRID 984222Notes

Reaction equation

HRID 984222 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][C:23](=O)[CH2:22][CH2:21]3)[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH2:27]([NH2:30])[C:28]#[CH:29]>>[CH2:27]([NH:30][CH:23]1[CH2:24][CH2:25][N:20]([CH2:19][C:17]2[CH:16]=[CH:15][N:14]=[C:13]([C:5]3[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:18]=2)[CH2:21][CH2:22]1)[C:28]#[CH:29]

Participants

3

Reactant 2

HCID 239041PropargylamineHCID 22557811[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl-4-piperidone

Product 1

HCID 22557994HCID 22557994, compound

Procedure

1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]-4-piperidone (400 mg) and propargylamine (80 mg) were reacted in the same manner as described in Preparation Example 25 to give the title compound.

Workup

  1. customas described in Preparation Example 25

Sources & evidence

ORD record
ord-9fbab061b1ff4b0e86982717f94e1730
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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