P-Anisidine → tert-butyl 4-(4-methoxyanilino)tetrahydro-1(2H)-pyridinecarboxylate

HRID 984237Notes

Reaction equation

HRID 984237 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=1>>[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23][CH:11]2[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:9][CH2:10]2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 2776119tert-butyl 4-(4-methoxyanilino)tetrahydro-1(2H)-pyridinecarboxylate

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (116 g) and p-anisidine (68.3 g) were condensed in the same manner as described in Preparation Example 37 to give the title compound.

Workup

  1. customcondensed in the same manner
  2. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-f149a3c7ace44158887740ef495a1dee
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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