4-Ethoxyaniline → 1-Boc-4-[(4-ethoxyphenyl)amino]-piperidine

HRID 984243Notes

Reaction equation

HRID 984243 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15][CH2:16][O:17][C:18]1[CH:19]=[CH:20][C:21]([NH2:24])=[CH:22][CH:23]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:24][C:21]2[CH:20]=[CH:19][C:18]([O:17][CH2:16][CH3:15])=[CH:23][CH:22]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 90764-EthoxyanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 225578601-Boc-4-[(4-ethoxyphenyl)amino]-piperidine

Procedure

1-(tert-butoxycarbonyl)-4-piperidinone (5.00 g) and p-phenetidine (3.28 g) was treated in the same manner as described in Preparation Example 37 to give brown powder of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-e4f0c7c8b37f4d9cb711ade4a0af57d4
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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