2-Methoxyaniline → tert-Butyl 4-((2-methoxyphenyl)amino)piperidine-1-carboxylate

HRID 984255Notes

Reaction equation

HRID 984255 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15][O:16][C:17]1[C:18]([NH2:23])=[CH:19][CH:20]=[CH:21][CH:22]=1>>[CH3:15][O:16][C:17]1[C:18]([NH:23][CH:11]2[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:9][CH2:10]2)=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 70002-MethoxyanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 22557919tert-Butyl 4-((2-methoxyphenyl)amino)piperidine-1-carboxylate

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (4.78 g) and o-anisidine (2.96 g) were condensed in the same manner as described in Preparation Example 37 to give the title compound.

Workup

  1. customcondensed in the same manner
  2. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-0648f59187df44a88b87e435d99b2ee2
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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