4-Fluoroaniline → tert-Butyl 4-(4-fluoroanilino)piperidine-1-carboxylate

HRID 984288Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:20][C:19]2[CH:21]=[CH:22][C:16]([F:15])=[CH:17][CH:18]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 97314-Fluoroaniline

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 16413902tert-Butyl 4-(4-fluoroanilino)piperidine-1-carboxylate

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and 4-fluoroaniline (2.66 g) was treated in the same manner as described in Preparation Example 37 to give white crystalline powder of the title compound.

Workup

customas described in Preparation Example 37

Sources & evidence

ORD record: ord-4e3ce2debc734481bff64ec544f0f5c9
Source dataset: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06867221B2

Reaction notes

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