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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 984288Generated: October 30, 2026

4-Fluoroaniline → tert-Butyl 4-(4-fluoroanilino)piperidine-1-carboxylate

https://huagongshe.com/reaction/984288

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-FluoroanilineHCID 9731—
Reactanttert-Butyl 4-oxopiperidine-1-carboxylateHCID 735900—
Producttert-Butyl 4-(4-fluoroanilino)piperidine-1-carboxylateHCID 16413902—

Reaction Steps

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and 4-fluoroaniline (2.66 g) was treated in the same manner as described in Preparation Example 37 to give white crystalline powder of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06867221B2
Source datasetuspto-grants-2005_03
ORD IDord-4e3ce2debc734481bff64ec544f0f5c9
Source noteuspto-grants-2005_03