Sodium Hydroxide → HCID 69800487, compound

HRID 984312Notes

Reaction equation

HRID 984312 reaction equation
C([O:3][C:4](=[O:30])[C@@H:5]([O:27][CH2:28][CH3:29])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH:15]=[CH:16][C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]=2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>C(O)C>[CH2:28]([O:27][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH:15]=[CH:16][C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]=2)=[CH:11][CH:12]=1)[C:4]([OH:30])=[O:3])[CH3:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69800548HCID 69800548, compound

Product 1

HCID 69800487HCID 69800487, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(S)-2-Ethoxy-3-[4-(3-quinolin-2-yl-allyloxy)-phenyl]-propionic acid ethyl ester (example 41) (150 mg, 0.37 mmol) was dissolved in ethanol (2 mL) and sodium hydroxide (1N, 2.0 mL, 2.0 mmol) added. The mixture was stirred at room temperature for 16 h. The reaction mixture was concentrated in vacuo, added 2-propanol (2 mL) and diethyl ether (2 mL). The title compound was isolated by filtration.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additionadded 2-propanol (2 mL) and diethyl ether (2 mL)

Sources & evidence

ORD record
ord-86720f8c5a6a40a2a63fe7b4806146b3
Source dataset
uspto-grants-2005_03
Patent number
US06867218B2

Reaction notes

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