Sodium Hydroxide → HCID 20765803, compound

HRID 984385Notes

Reaction equation

[CH2:1]([O:3][C@@H:4]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18]/[CH:19]=[CH:20]/[C:21]2[CH:22]=[C:23]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH:24]=[C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH:26]=2)=[CH:13][CH:12]=1)[C:5]([O:7]CC)=[O:6])[CH3:2].[OH-].[Na+]>>[CH2:1]([O:3][C@@H:4]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][CH2:18]/[CH:19]=[CH:20]/[C:21]2[CH:26]=[C:25]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH:24]=[C:23]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH:22]=2)=[CH:15][CH:16]=1)[C:5]([OH:7])=[O:6])[CH3:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 20765809HCID 20765809, compound

Product 1

HCID 20765803HCID 20765803, compoundYield 92%

Procedure

The title compound was prepared from (E)-(S)-ethyl 2-ethoxy-3-[4-(3-[1,1′;3′,1″]terphenyl-5′-yl-allyloxy)-phenyl]-propionate (Example 109) (405 mg, 0.8 mmol) and sodium hydroxide (1M, 1.6 ml, 1.6 mmol) by a procedure analogous to that described in example 51, yielding (E)-(S)-2-ethoxy-3-[4-(3-[1,1′;3′,1″]terphenyl-5′-yl-allyloxy)-phenyl]-propionic acid (352 mg, 92%) as a colourless glass.

Sources & evidence

ORD record: ord-bbc5a0d6cd014303b15af1a9ee059cdc
Source dataset: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06867218B2

Reaction notes

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