反应详情

A solution of 2-amino-6-bromonaphthalene (2.0 g) in 1,4-dioxane (30 ml) was added dropwise with dimethyl sulfate (1300 μl) and stirred at room temperature for 46 hours. The reaction mixture was added with ethyl acetate (90 ml) and then added with 1 N aqueous sodium hydroxide (5 ml). This mixture was extracted with ethyl acetate (150 ml×3). The organic layer was washed with saturated brine and dried, and then the solvent was evaporated under reduced pressure. The residue was purified by flash column chromatography (hexane:ethyl acetate=15:1) to obtain the title compound (Intermediate 27, 152 mg).

1. extractionThis mixture was extracted with ethyl acetate (150 ml×3)
2. washThe organic layer was washed with saturated brine
3. customdried
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was purified by flash column chromatography (hexane:ethyl acetate=15:1)