Hydrochloric Acid → HCID 22558802, compound

HRID 984709Notes

Reaction equation

HRID 984709 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:5][C:4]=1[C:14]1[CH:23]=[CH:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=1.N1C=CC=C[CH:25]=1.Cl.S(Cl)(Cl)=O>CO>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([O:13][CH3:25])=[O:12])=[CH:5][C:4]=1[C:14]1[CH:23]=[CH:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 24386Thionyl ChlorideHCID 22559255HCID 22559255, compound

Product 1

HCID 22558802HCID 22558802, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to the procedure described in the synthesis method of Intermediate 20 in Reference Example 6 (Step f), Intermediate 35 (551 mg), pyridine and concentrated hydrochloric acid (5 ml each) were reacted and treated. According to the procedure described in the synthesis method of Intermediate 1 in Reference Example 1 (Step c), the obtained residue was reacted with thionyl chloride (0.33 ml) in methanol to obtain the title compound (Intermediate 36, 531 mg).

Workup

  1. customwere reacted
  2. additiontreated

Sources & evidence

ORD record
ord-e5113fc0f3974bd9ac48a5d727bf7a83
Source dataset
uspto-grants-2005_03
Patent number
US06867320B2

Reaction notes

Loading…