Hydrochloric Acid → HCID 21388870, compound

HRID 984787Notes

Reaction equation

HRID 984787 reaction equation
[C:1]([NH2:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:10]>>[ClH:10].[CH2:4]([C:5]1[CH:6]=[CH:7][C:2]([C:1]([NH2:9])=[O:8])=[CH:3][CH:4]=1)[CH2:3][CH2:2][CH2:7][CH3:6]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 2331Benzamide

Product 1

HCID 21388870HCID 21388870, compoundYield 94%

Procedure

A solution of the benzamide of part E (2.09 g, 3.4 mmol) in 4N HCl (20 mL) was stirred for 72 hours. The solution was concentrated in vacuo and the residue was dissolved into ethyl acetate (5 mL) and dropped into ethyl ether. The resulting precipitate was collected by vacuum filtration to provide R-N-[4-[[[1-carboxyl]-2-methylpropyl][2-(4-orpholinyl)ethyl]amino]-sulfonyl]phenyl]-4-pentylbenzamide monohydrochloride as white solid (1.9 g, 94%).

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. dissolutionthe residue was dissolved into ethyl acetate (5 mL)
  3. additiondropped into ethyl ether
  4. filtrationThe resulting precipitate was collected by vacuum filtration

Sources & evidence

ORD record
ord-fb4fe40546b0470dbc1aea8b410586c8
Source dataset
uspto-grants-2005_03
Patent number
US06869951B1

Reaction notes

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