Ethane, 2-bromo-1,1-diethoxy- → HCID 15888248, compound

HRID 984797Notes

Reaction equation

HRID 984797 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[N:11]1[C:20]2[N:19]=[C:18]([CH3:21])[N:17]=[C:16]([N:22]([CH2:27][CH3:28])[CH2:23][CH2:24][CH2:25][CH3:26])[C:15]=2[NH:14][C:13](=[NH:29])[CH2:12]1.[CH2:30](OC(OCC)CBr)[CH3:31]>C(O)C>[Br:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:9])[CH3:10])[CH:5]=[CH:4][C:3]=1[N:11]1[C:20]2[C:15](=[C:16]([N:22]([CH2:23][CH2:24][CH2:25][CH3:26])[CH2:27][CH3:28])[N:17]=[C:18]([CH3:21])[N:19]=2)[N:14]2[CH:30]=[CH:31][N:29]=[C:13]2[CH2:12]1

Participants

4

Reactant 2

HCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 178449019HCID 178449019, compound

Product 1

HCID 15888248HCID 15888248, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of the compound of Example 248 and a slight excess of bromoacetaldehyde diethyl acetal in ethanol is heated to reflux until the starting material is consumed. The reaction mixture is evaporated, and the residual material is purified by chromatography or recrystallization to afford the title product.

Workup

  1. temperatureto reflux until the starting material
  2. customis consumed
  3. customThe reaction mixture is evaporated
  4. customthe residual material is purified by chromatography or recrystallization

Sources & evidence

ORD record
ord-ed300ab00e1a42829531f8c5d06de25d
Source dataset
uspto-grants-2005_03
Patent number
US06869955B2

Reaction notes

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