Benzyl Bromide → 7-Benzyl-8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

HRID 984824Notes

Reaction equation

HRID 984824 reaction equation
[Cl:1][C:2]1[NH:11][C:10]2[C:9](=[O:12])[N:7]([CH3:8])[C:6](=[O:13])[N:5]([CH3:14])[C:4]=2[N:3]=1.[CH2:15](Br)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([N:11]1[C:10]2[C:9](=[O:12])[N:7]([CH3:8])[C:6](=[O:13])[N:5]([CH3:14])[C:4]=2[N:3]=[C:2]1[Cl:1])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 106618-Chlorotheophylline

Product 1

HCID 3253727-Benzyl-8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

Procedure

From 8-Chlorotheophylline (50 g, 233 mmol) and benzyl bromide. The reaction mixture was evaporated to dryness in vacuo, dissolved in DCM (400 ml) and water (250 ml). The separated aqueous phase was extracted with DCM (150 ml), and the combined DCM phases were washed with brine, dried (MgSO4), and evaporated in vacuo.

Workup

  1. customThe reaction mixture was evaporated to dryness in vacuo
  2. dissolutiondissolved in DCM (400 ml)
  3. extractionThe separated aqueous phase was extracted with DCM (150 ml)
  4. washthe combined DCM phases were washed with brine
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

Sources & evidence

ORD record
ord-ac877df2eada4f6e8c33af60dfc1f511
Source dataset
uspto-grants-2005_03
Patent number
US06869947B2

Reaction notes

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