Hydrochloric Acid → HCID 178431468, compound

HRID 984869Notes

Reaction equation

[CH3:1][S:2]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[C:10]([CH3:25])=[C:11]2[N:16]([CH:17]=1)[N:15]=[CH:14][N:13]=[C:12]2[O:18]C1C=CC=CC=1)(=[O:4])=[O:3].Cl>C(O)C>[CH3:1][S:2]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[C:10]([CH3:25])=[C:11]2[N:16]([CH:17]=1)[N:15]=[CH:14][N:13]=[C:12]2[OH:18])(=[O:4])=[O:3]

Participants

Conditions

Temperature: 80 °C

Procedure

A mixture of 6-(3-methanesulfonyl-propoxy)-5-methyl-4-phenoxypyrrolo[2,1-f][1,2,4]triazine (1.1 g, 3.04 mmol), HCl (1N, 20 mL) and ethanol (20 mL) was heated at 80° C. for 3 h. The volatiles were removed in vacuo. The white solid was triturated with diethyl ether/hexane (2:1) to afford 6-(3-methanesulfonyl-propoxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-ol (820 mg, 95%) as a white solid MS: (M+H)+=286.

Workup

customThe volatiles were removed in vacuo
customThe white solid was triturated with diethyl ether/hexane (2:1)

Sources & evidence

ORD record: ord-d5829e7458d2438b96ddb92d7a64aa88
Source dataset: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06869952B2

Reaction notes

Loading…