反应详情

温度

110 °C

A mixture of ethyl 2-chloropyrimidine-5-carboxylate (335 mg), 3,5-di-tert-butylaniline (370 mg), and K2CO3 (600 mg) was heated at 110° C. After the disappearance of the materials was observed with TLC, the reaction mixture was poured into water, and extracted with CH2Cl2. The organic layer was dried over Na2SO4, and the solvent was evaporated. The residue was purified by silica gel flash column chromatography (n-hexane: AcOEt=10:1) to give white crystals of ethyl 2-[N-(3,5-di-tert-butylphenyl)amino]pyrimidine-5-carboxylate (574 mg, 90%).

1. extractionextracted with CH2Cl2
2. dry with materialThe organic layer was dried over Na2SO4
3. customthe solvent was evaporated
4. customThe residue was purified by silica gel flash column chromatography (n-hexane: AcOEt=10:1)