Diisobutylaluminum hydride → HCID 69796253, compound

HRID 984957Notes

Reaction equation

HRID 984957 reaction equation
C([O:3][C:4](=O)/[CH:5]=[C:6](/[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)\[CH3:7])C.CC(C[AlH]CC(C)C)C>>[Br:20][C:17]1[CH:16]=[CH:15][C:14]([C:11]2[CH:12]=[CH:13][C:8](/[C:6](/[CH3:7])=[CH:5]/[CH2:4][OH:3])=[CH:9][CH:10]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 14487Diisobutylaluminum hydrideHCID 22718800HCID 22718800, compound

Product 1

HCID 69796253HCID 69796253, compound

Procedure

(E)-3-(4′-bromo-biphenyl-4-yl)-but-2-en-1-ol was prepared from (E)-3-(4′-bromo-biphenyl-4-yl)-but-2-enoic acid ethyl ester (3.45 g, 10.0 mmol) and DIBAL-H (1M in toluene, 40 mL, 40 mmol) by a procedure analogous to that described in example 11 step B, yielding 1.68 g (55%).

Workup

  1. customyielding 1.68 g (55%)

Sources & evidence

ORD record
ord-fd9abd830283412095c81de60a67c83b
Source dataset
uspto-grants-2005_03
Patent number
US06869967B2

Reaction notes

Loading…