6-(4-Fluoro-3-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-one → 6-(4-Fluoro-3-methylphenyl)-2-isobutyl-4-methylaminomethyl-2h-pyridazin-3-one

HRID 984990Notes

Reaction equation

HRID 984990 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:19](OC)=O)[C:11](=[O:18])[N:12]([CH2:14][CH:15]([CH3:17])[CH3:16])[N:13]=2)=[CH:4][C:3]=1[CH3:23].FC1C=CC(C2C=C(COS(C)(=O)=O)[C:34](=O)[N:35](CC(C)C)N=2)=CC=1C>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([CH2:19][NH:35][CH3:34])[C:11](=[O:18])[N:12]([CH2:14][CH:15]([CH3:17])[CH3:16])[N:13]=2)=[CH:4][C:3]=1[CH3:23]

Participants

3

Reactant 2

HCID 219914576-(4-Fluoro-3-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-oneHCID 219915336-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 219915416-(4-Fluoro-3-methylphenyl)-2-isobutyl-4-methylaminomethyl-2h-pyridazin-3-oneYield 96.2%

Procedure

Following the procedure of Example 9 (4), 6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one was reacted to yield the title compound as a pale yellow oil (yield: 96.2%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-32b0c238cef042e9b07b8e9fbd2b4dfa
Source dataset
uspto-grants-2005_03
Patent number
US06869954B2

Reaction notes

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