Diethylamine → 4-diethylaminomethyl-6-(4-fluoro-3-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

HRID 984993Notes

Reaction equation

HRID 984993 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:19](OC)=O)[C:11](=[O:18])[N:12]([CH2:14][CH:15]([CH3:17])[CH3:16])[N:13]=2)=[CH:4][C:3]=1[CH3:23].FC1C=CC(C2C=[C:33](COS(C)(=O)=O)[C:34](=O)[N:35]([CH2:37][CH:38](C)C)N=2)=CC=1C.C(NCC)C>>[CH2:34]([N:35]([CH2:19][C:10]1[C:11](=[O:18])[N:12]([CH2:14][CH:15]([CH3:17])[CH3:16])[N:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([CH3:23])[CH:4]=2)[CH:9]=1)[CH2:37][CH3:38])[CH3:33]

Participants

4

Reactant 3

HCID 8021DiethylamineHCID 219914576-(4-Fluoro-3-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-oneHCID 219915336-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 219915944-diethylaminomethyl-6-(4-fluoro-3-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

Procedure

Following the procedure of Example 9 (4), 6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and diethylamine were reacted to yield the title compound as a slightly yellow oil (yield: 94.7%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-0451f153ee6f4cd08c81792be3309cfe
Source dataset
uspto-grants-2005_03
Patent number
US06869954B2

Reaction notes

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