1-Methylpiperazine → HCID 67213231, compound

HRID 985004Notes

Reaction equation

HRID 985004 reaction equation
[Cl:1][C:2]1[CH:31]=[CH:30][C:5]([CH:6]=[CH:7][CH2:8][N:9]2[C:14](=[O:15])[C:13]([CH2:16]OS(C)(=O)=O)=[CH:12][C:11]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[C:24]([CH3:29])[CH:23]=3)=[N:10]2)=[CH:4][CH:3]=1.[CH3:32][N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]=[CH:7][CH2:8][N:9]2[C:14](=[O:15])[C:13]([CH2:16][N:36]3[CH2:37][CH2:38][N:33]([CH3:32])[CH2:34][CH2:35]3)=[CH:12][C:11]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[C:24]([CH3:29])[CH:23]=3)=[N:10]2)=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 738582892-(4-chlorocinnamyl)-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one

Product 1

HCID 67213231HCID 67213231, compoundYield 71.8%

Procedure

Following the procedure of Example 1(10), 2-(4-chlorocinnamyl)-6-(4-fluoro-3-methylphenyl)-4-methane-sulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 71.8%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-7af799cc33bf4042a4051b12c4fc9d67
Source dataset
uspto-grants-2005_03
Patent number
US06869954B2

Reaction notes

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