2,5-Dimethyl-4-[[2-methyl-4-[(4-trifluoromethyl-phenylamino)methyl]phenyl]sulfanyl]-phenoxy-acetic acid ethyl ester → 2,5-Dimethyl-4-[[2-methyl-4-[(4-trifluoromethyl-phenylamino)methyl]phenyl]sulfanyl]-phenoxy-acetic acid
Reaction equation
FC(F)(F)C1C=CC(OCC2C=CC(SC3C=CC(OCC(O)=O)=C(C)C=3)=CC=2)=CC=1.C([O:34][C:35](=[O:66])[CH2:36][O:37][C:38]1[CH:43]=[C:42]([CH3:44])[C:41]([S:45][C:46]2[CH:51]=[CH:50][C:49]([CH2:52][NH:53][C:54]3[CH:59]=[CH:58][C:57]([C:60]([F:63])([F:62])[F:61])=[CH:56][CH:55]=3)=[CH:48][C:47]=2[CH3:64])=[CH:40][C:39]=1[CH3:65])C>>[CH3:65][C:39]1[CH:40]=[C:41]([S:45][C:46]2[CH:51]=[CH:50][C:49]([CH2:52][NH:53][C:54]3[CH:59]=[CH:58][C:57]([C:60]([F:62])([F:61])[F:63])=[CH:56][CH:55]=3)=[CH:48][C:47]=2[CH3:64])[C:42]([CH3:44])=[CH:43][C:38]=1[O:37][CH2:36][C:35]([OH:66])=[O:34]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared according to the method described for preparing compound 7, using compound 21.5 as starting material. MS APSI m/e: 474 (M−H). 1H NMR (400 MHz) (DMSO-d6) δ 12.86 (1H, brs); 7.33 (2H, d, J=8.6 Hz); 7.21 (1H, s); 7.12 (1H, s); 7.05 (1H, d, J=8.1 Hz); 6.87 (1H, s); 6.85 (1H, t, J=5.6 Hz); 6.65 (2H, d, J=8.6 Hz); 6.62 (1H, d, J=8.1 Hz); 4.72 (2H, s); 4.22 (2H, d, J=5.6 Hz); 2.30 (3H, s); 2.23 (3H, s); 2.11 (3H, s).
Sources & evidence
- ORD record
- ord-a13b14510f84453a973e7d7eafbd3117
- Source dataset
- uspto-grants-2005_03
- Patent number
- US06869975B2
Reaction notes
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