[4-(2-Chloro-4-formyl-phenylsulfanyl)-2,5-dimethyl-phenoxy]-acetic acid ethyl ester → [4-(2-Chloro-4-hydroxymethyl-phenylsulfanyl)-2,5-dimethyl-phenoxy]-acetic acid ethyl ester

HRID 985069Notes

Reaction equation

HRID 985069 reaction equation
C(OC(=O)COC1C=CC(SC2C=CC(CO)=CC=2Cl)=CC=1C)C.[CH2:25]([O:27][C:28](=[O:49])[CH2:29][O:30][C:31]1[CH:36]=[C:35]([CH3:37])[C:34]([S:38][C:39]2[CH:44]=[CH:43][C:42]([CH:45]=[O:46])=[CH:41][C:40]=2[Cl:47])=[CH:33][C:32]=1[CH3:48])[CH3:26]>>[CH2:25]([O:27][C:28](=[O:49])[CH2:29][O:30][C:31]1[CH:36]=[C:35]([CH3:37])[C:34]([S:38][C:39]2[CH:44]=[CH:43][C:42]([CH2:45][OH:46])=[CH:41][C:40]=2[Cl:47])=[CH:33][C:32]=1[CH3:48])[CH3:26]

Participants

3

Reactant 2

HCID 20768115[4-(2-Chloro-4-formyl-phenylsulfanyl)-2,5-dimethyl-phenoxy]-acetic acid ethyl esterHCID 207681184-[(2-Chloro-4-hydroxymethylphenyl)sulfanyl]-2-methylphenoxy-acetic acid ethyl ester

Product 1

HCID 20768117[4-(2-Chloro-4-hydroxymethyl-phenylsulfanyl)-2,5-dimethyl-phenoxy]-acetic acid ethyl ester

Procedure

The title compound was prepared according to the method described for preparing compound 10.5, using compound 24.1 as the starting material. 1H NMR (400 MHz) (CDCl3) δ 7.36 (1H, d, J=1.6 Hz); 7.33 (1H, s); 7.01 (1H, dd, J=1.9, 8.1 Hz); 6.67 (1H, s); 6.50 (1H, d, J=8.2 Hz); 4.68 (2H, s); 4.60 (2H, s); 4.30 (2H, q, J=7.2 Hz); 2.31 (3H, s); 2.25 (3H, s); 1.67 (1H, brs); 1.32 (3H, t, J=7.2 Hz).

Sources & evidence

ORD record
ord-07189280501341f19d31ae4b41716945
Source dataset
uspto-grants-2005_03
Patent number
US06869975B2

Reaction notes

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