反应详情

A mixture of 31.8 g of 2-amino-3,5-dibromopyridine, 22 g of 3-bromo-2-butanone and 350 ml of tetrahydrofuran is heated at reflux for 9 days, and the precipitate formed is filtered off and dried in vacuo. It is then suspended in 1 l of water and adjusted to pH 8 using 6 molar aqueous sodium hydroxide solution. The precipitate formed here is filtered off and washed with water. 28 g of the title compound of melting point over 90° C. (sintering) are obtained.

1. temperatureis heated
2. temperatureat reflux for 9 days
3. customthe precipitate formed
4. filtrationis filtered off
5. customdried in vacuo
6. customThe precipitate formed here
7. filtrationis filtered off
8. washwashed with water
9. customover 90° C.
10. customare obtained