Hydroxyacetonitrile → HCID 20768298, compound

HRID 985156Notes

Reaction equation

HRID 985156 reaction equation
[C:1](#[N:4])[CH2:2]O.[C:5]([O:9][C:10](=[O:15])[NH:11][CH2:12][CH2:13][NH2:14])([CH3:8])([CH3:7])[CH3:6]>C(O)C>[C:5]([O:9][C:10](=[O:15])[NH:11][CH2:12][CH2:13][NH:14][CH2:2][C:1]#[N:4])([CH3:8])([CH3:6])[CH3:7]

Participants

4

Reactant 2

HCID 7857HydroxyacetonitrileHCID 187201N-BOC-ethylenediamine

Product 1

HCID 20768298HCID 20768298, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Glycolonitrile (70%, 5.10 g, 62.5 mmol), tert-butyl-N-(2-aminoethyl)carbamate (10.0 g, 62.5 mmol), and ethanol (200 mL) were combined under Ar and heated at reflux for 4 h. Removal of the solvent in vacuo gave 111 as a yellow oil.

Workup

  1. temperatureheated
  2. temperatureat reflux for 4 h
  3. customRemoval of the solvent in vacuo

Sources & evidence

ORD record
ord-76bdbfbc32a1462c9f069cf097528bde
Source dataset
uspto-grants-2005_03
Patent number
US06870055B2

Reaction notes

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