Ammonium Hydroxide → HCID 20768296, compound

HRID 985159Notes

Reaction equation

HRID 985159 reaction equation
[C:1]([O:5][C:6](=[O:31])[NH:7][CH2:8][CH2:9][N:10]1[C:19]([C:20]#[N:21])=[C:18]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:28][CH3:29])[CH:16]=2)[C:11]1=[O:30])([CH3:4])([CH3:3])[CH3:2].[OH-].[NH4+]>[Ni].C(O)C>[C:1]([O:5][C:6](=[O:31])[NH:7][CH2:8][CH2:9][N:10]1[C:19]([CH2:20][NH2:21])=[C:18]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:28][CH3:29])[CH:16]=2)[C:11]1=[O:30])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 14923Ammonium HydroxideHCID 11362125HCID 11362125, compound

Product 1

HCID 20768296HCID 20768296, compoundYield 88.6%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A suspension of 113 (3.04 g, 7.26 mmol), raney nickel, ammonium hydroxide (10 mL), and ethanol (50 mL) were combined in a Parr jar and hydrogenated at 55 psi for 18 h. The contents of the Parr jar were filtered through Celite and the filtrate was rotary evaporated to give 114 as a white solid (2.72 g, 6.43 mmol, 88.6%).

Workup

  1. filtrationThe contents of the Parr jar were filtered through Celite
  2. customthe filtrate was rotary evaporated

Sources & evidence

ORD record
ord-b27ce7b9103d4590a105db4ecd792990
Source dataset
uspto-grants-2005_03
Patent number
US06870055B2

Reaction notes

Loading…