Trifluoroacetic acid → HCID 69733493, compound

HRID 985172Notes

Reaction equation

HRID 985172 reaction equation
[CH2:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([O-:9])=[O:8])=[C:5]([OH:12])[C:4]=1[CH2:13][NH:14][C:15](=[O:29])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:21]C(OC(C)(C)C)=O)[CH3:2].[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>ClCCl>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[CH2:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[C:5]([OH:12])[C:4]=1[CH2:13][NH:14][C:15](=[O:29])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH2:21])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178436470HCID 178436470, compound

Product 1

HCID 69733493HCID 69733493, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Ethyl(N-tert-butoxycarbonyl-6-aminohexanoyl)aminomethyl-2-hydroxybenzoate (0.58 g, 1.41 mmoles) was dissolved in dichloromethane (5 mL) and the solution was cooled in an ice/water bath. Trifluoroacetic acid (5 mL) was added, and the reaction was allowed to warm to room temperature. After 2 hours, the reaction mixture was evaporated to dryness to give the product as an oil, which was dried in vacuo over potassium hydroxide pellets to afford 0.59 g (99% yield) of ethyl (6-aminohexanoyl)aminomethyl-2-hydroxybenzoate trifluoroacetate.

Workup

  1. temperaturethe solution was cooled in an ice/water bath
  2. customthe reaction mixture was evaporated to dryness

Sources & evidence

ORD record
ord-c36bf4f72e3b4074b9f6cc35c7cc93a9
Source dataset
uspto-grants-2005_03
Patent number
US06870065B2

Reaction notes

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