反应详情

A mixture of 2-fluoro-4-bromothiophenol (300 mg), 2,6-dichloro-pyridazine (149 mg), potassium carbonate (400 mg) and acetone (6 mL) was prepared and refluxed for two hours. The acetone from the mixture was evaporated and the resulting residue was dissolved in a solution of methanol (3 mL) and sodium metal (166 mg). The resulting solution was refluxed for 1 hour. Evaporation of methanol afforded 3-(4-bromo-2-fluoro-phenylsulfanyl)-6-methoxy-pyridazine, which was not isolated but was immediately used in Step 2.

1. customwas prepared
2. temperaturerefluxed for two hours
3. customThe acetone from the mixture was evaporated
4. dissolutionthe resulting residue was dissolved in a solution of methanol (3 mL) and sodium metal (166 mg)
5. temperatureThe resulting solution was refluxed for 1 hour
6. customEvaporation of methanol