Hydrochloric Acid → HCID 9967430, compound

HRID 985397Notes

Reaction equation

HRID 985397 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[N:12]=[N:13][C:14]([O:17]C)=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[C:4]([F:19])[CH:3]=1.Cl>O1CCOCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][C:14](=[O:17])[NH:13][N:12]=2)(=[O:10])=[O:9])=[C:4]([F:19])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22506951HCID 22506951, compound

Product 1

HCID 9967430HCID 9967430, compoundYield 90.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 3-(4-bromo-2-fluoro-benzenesulfonyl)-6-methoxy-pyridazine (260 mg), dioxane (5 mL), and concentrated hydrochloric acid (1 mL) was prepared and refluxed for two hours. The reaction mixture was then evaporated to dryness. The resulting residue was triturated with water and the precipitated solid was collected and air-dried to obtain the title compound (90%, 225 mg); mp, >220° C.; NMR 7.05 (d, 1H), 7.7 (d, 1H), 7.9 (m, 3H), 13.8 (s, 1H).

Workup

  1. customwas prepared
  2. temperaturerefluxed for two hours
  3. customThe reaction mixture was then evaporated to dryness
  4. customThe resulting residue was triturated with water
  5. customthe precipitated solid was collected
  6. customair-dried

Sources & evidence

ORD record
ord-0f8f821892ee4dd8a0cafff8e9c16bfd
Source dataset
uspto-grants-2005_03
Patent number
US06872722B2

Reaction notes

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