Hydrochloric Acid → 6-Oxo-1,6-dihydro-pyridazine-3-sulfonic Acid methyl-phenyl-amide

HRID 985405Notes

Reaction equation

HRID 985405 reaction equation
[CH3:1][N:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[S:3]([C:6]1[N:7]=[N:8][C:9]([O:12]C)=[CH:10][CH:11]=1)(=[O:5])=[O:4].Cl>O1CCOCC1>[CH3:1][N:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[S:3]([C:6]1[CH:11]=[CH:10][C:9](=[O:12])[NH:8][N:7]=1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 697035156-Methoxy-pyridazine-3-sulfonic acid methyl-phenyl-amide

Product 1

HCID 98784626-Oxo-1,6-dihydro-pyridazine-3-sulfonic Acid methyl-phenyl-amideYield 75.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 6-methoxy-pyridazine-3-sulfonic acid methyl-phenyl-amide (239 mg), dioxane (4 mL) and concentrated hydrochloric acid (1 mL) was prepared and refluxed for one hour. The mixture was then evaporated to dryness. The resulting solid was triturated with water and the solid was collected to afford the title compound (75%, 171 mg); mp, 157-158° C.

Workup

  1. customwas prepared
  2. temperaturerefluxed for one hour
  3. customThe mixture was then evaporated to dryness
  4. customThe resulting solid was triturated with water
  5. customthe solid was collected

Sources & evidence

ORD record
ord-c8ec633da89f4045a7243ece7df3f351
Source dataset
uspto-grants-2005_03
Patent number
US06872722B2

Reaction notes

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