HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thymidine, 5'-azido-5'-deoxy- → 5'-Amino-5'-deoxythymidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thymidine, 5'-azido-5'-deoxy- | HCID 451456 | — |
| Catalyst | HCID 178418361 | HCID 178418361 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5'-Amino-5'-deoxythymidine | HCID 65311 | — |
Reaction Steps
The thus-obtained 5′-azido-5′-deoxythymidine was then dissolved in methanol and reduced with hydrogen using 10% palladium/carbon as a catalyst, whereby 5′-amino-5′-deoxythymidine was obtained. Yield 1.734 g, 71.6%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872809B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-0ebf3c2fc8c347798e750b9ed672c3a4 |
| Source note | uspto-grants-2005_03 |