Potassium Carbonate → HCID 85792394, compound

HRID 985720Notes

Reaction equation

HRID 985720 reaction equation
[C:1](=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][CH2:9][CH2:10][O:11][CH2:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][CH:14]=1>CO>[C:17]([C:16]1[CH:19]=[CH:20][C:13]([CH2:12][O:11][CH2:10][CH2:9][O:8][CH3:7])=[CH:14][CH:15]=1)#[CH:1]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 85792393HCID 85792393, compound

Product 1

HCID 85792394HCID 85792394, compoundYield 67.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dimethyl[(2-diazo-3-oxo)propyl] phosphonate was added in 4 portions to a suspension of potassium carbonate (4.96 g, 36 mmol), the product of Step B (3.78 g, 18 mmol), and methanol (50 mL). The reaction was stirred for 16 hours. and concentrated in vacuo. The residue was taken up in ether, washed with water (3×), dried (potassium carbonate), and concentrated. The crude product was purified by silica gel chromatography (hexane:ethyl acetate) to provide the title compound (2.3 g).

Workup

  1. concentrationand concentrated in vacuo
  2. washwashed with water (3×)
  3. dry with materialdried (potassium carbonate)
  4. concentrationconcentrated
  5. customThe crude product was purified by silica gel chromatography (hexane:ethyl acetate)

Sources & evidence

ORD record
ord-b7a7ef68887f4671a610da178cb570cf
Source dataset
uspto-grants-2005_03
Patent number
US06872834B2

Reaction notes

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