Hydrochloric Acid → HCID 22507783, compound

HRID 985721Notes

Reaction equation

HRID 985721 reaction equation
COCCOC[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]([S:22]([CH3:25])(=[O:24])=[O:23])[C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:9][CH:8]=1.Cl.C[OH:28]>>[OH:28][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]([S:22]([CH3:25])(=[O:24])=[O:23])[C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:9][CH:8]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 68901562HCID 68901562, compound

Product 1

HCID 22507783HCID 22507783, compound

Procedure

A solution of the product of Step D (1.5 g, 4.0 mmol) in methanol (10 mL) was treated with HCl (10 mL, 4 N in dioxane). The reaction was allowed to stir for 2 hr, concentrated, and purified by silica gel chromatography (methanol:dichloromethane), to afford the title compound (0.93 g).

Workup

  1. concentrationconcentrated
  2. custompurified by silica gel chromatography (methanol:dichloromethane)

Sources & evidence

ORD record
ord-82f05794caf94f94b1e4a59dd4a7b25a
Source dataset
uspto-grants-2005_03
Patent number
US06872834B2

Reaction notes

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