Hydrochloric Acid → 4-(p-Fluorophenyl)butyric acid

HRID 985761Notes

Reaction equation

HRID 985761 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([O:13]C)=[O:12])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 140723Methyl 4-(4-fluorophenyl)butanoate

Product 1

HCID 685244-(p-Fluorophenyl)butyric acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.076 mol of the compound obtained in Step C is introduced in a 500 ml round-bottomed flask, and then 250 ml of water and 0.152 mol of NaOH are added. The reaction mixture is stirred for 12 hours at ambient temperature. The reaction mixture is then acidified with 3M HCl and is extracted twice with ethyl ether. The organic phase is dried over MgSO4 and evaporated under reduced pressure to obtain the title product in the form of a white solid.

Workup

  1. extractionis extracted twice with ethyl ether
  2. dry with materialThe organic phase is dried over MgSO4
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-ee8f44f2cae14453ae9af3d05553d4c1
Source dataset
uspto-grants-2005_03
Patent number
US06872851B1

Reaction notes

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