Diisopropylethylamine → HCID 22507746, compound

HRID 985831Notes

Reaction equation

HRID 985831 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[CH3:12])[C:6]([OH:8])=O.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C.[O:46]1[CH2:51][CH2:50][O:49][CH2:48][CH:47]1[C:52]1[C:60]2[S:59][C:58]([NH2:61])=[N:57][C:56]=2[C:55]([O:62][CH3:63])=[CH:54][CH:53]=1>C(Cl)(Cl)Cl>[O:46]1[CH2:51][CH2:50][O:49][CH2:48][CH:47]1[C:52]1[C:60]2[S:59][C:58]([NH:61][C:6](=[O:8])[C:5]3[CH:9]=[CH:10][C:11]([CH3:12])=[C:3]([O:2][CH3:1])[CH:4]=3)=[N:57][C:56]=2[C:55]([O:62][CH3:63])=[CH:54][CH:53]=1

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 815794-Methyl-m-anisic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 22507697(+)-7-[1,4)Dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine

Product 1

HCID 22507746HCID 22507746, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

From 3-methoxy-4-methylbenzoic acid, HATU and N-ethyldiisopropylamine in THP, then treatment with (+)-7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine. [α]D20=+23.0° (c=1.03, CHCl3), ES-MS m/e (%): 415 (M+H+, 100).

Sources & evidence

ORD record
ord-d58687ecc5374f779c4b510a8a5848fa
Source dataset
uspto-grants-2005_03
Patent number
US06872833B2

Reaction notes

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