反应详情

温度

70 °C

A pre-mix of 23.3 g of NaOH, 2.5 g of tetrabutylammonium iodide, 107 ml of water, 25 ml of toluene and 9 ml of tetrahydrofuran under argon was heated to 70° C. A mixture of 70 g (0.5 moles) of 3-methylbenzyl chloride and 50.4 g (0.7 moles) of isobutyraldehyde was added dropwise to this pre-mix within a period of 2 hours while stirring vigorously. The reaction mixture was then maintained at a temperature of 75° C. for 3 hours. After separating the phases and removing the solvents, 66.5 g of end product were obtained by fractional distillation at 0.12 mbar in a temperature range of from 50° C. to 52° C.

1. additionwas added dropwise to
2. additionthis pre-mix within a period of 2 hours
3. temperatureThe reaction mixture was then maintained at a temperature of 75° C. for 3 hours
4. customAfter separating the phases
5. customremoving the solvents, 66.5 g of end product
6. customwere obtained by fractional distillation at 0.12 mbar in a temperature range of from 50° C. to 52° C.