Hydrochloric Acid → HCID 13797315, compound

HRID 985906Notes

Reaction equation

HRID 985906 reaction equation
[CH3:1][C:2]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[CH:9]=1)([CH2:5][CH3:6])[CH:3]=[O:4].[BH4-].[Na+].Cl>C(O)C>[CH3:1][C:2]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[CH:9]=1)([CH2:5][CH3:6])[CH2:3][OH:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydride2×HCID 13797314HCID 13797314, compound

Product 1

HCID 13797315HCID 13797315, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

29 g of 2-methyl-2-(3-methylbenzyl)-butyraldehyde (according to Example 11) were stirred for 20 hours at room temperature with 3 g of sodium borohydride in 80 ml of ethanol. Excess sodium borohydride was then decomposed with 2N HCl. After removing the ethanol, the residue was taken up in ether and extracted with water. The organic phase was extracted by shaking with 2N NaOH and water and dried with solid potassium carbonate. After removing the solvent, fractional distillation was carried out. 20 g of end product were obtained in a temperature range of from 72° C. to 73° C. at 0.12 mbar.

Workup

  1. customAfter removing the ethanol
  2. extractionextracted with water
  3. extractionThe organic phase was extracted
  4. dry with materialdried with solid potassium carbonate
  5. customAfter removing
  6. distillationthe solvent, fractional distillation
  7. custom20 g of end product were obtained in a temperature range of from 72° C. to 73° C. at 0.12 mbar

Sources & evidence

ORD record
ord-694060b480f14717b6635b730b01c43b
Source dataset
uspto-grants-1987_12
Patent number
US04710316

Reaction notes

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