反应详情

A stirred solution of 2-methoxy-8-methyl-6-(3-pyridyl)quinoline (1.07 g) in 5M hydrochloric acid (10 cm3) was heated under reflux for 2.5 hours and then cooled. The cooled solution was basified to pH 9 with 2M aqueous sodium hydroxide, extracted with chloroform:methanol 9:1 (4×100 cm3), and the combined and dried (MgSO4) extracts were concentrated in vacuo to afford a solid. Recrystallisation of the solid from ethyl acetate-methanol gave 8-methyl-6-(3-pyridyl)-2-(1H)-quinolone, m.p. 235.5°-236.5°, (0.63 g).

1. temperatureunder reflux for 2.5 hours
2. temperaturecooled
3. extractionextracted with chloroform:methanol 9:1 (4×100 cm3)
4. dry with materialdried (MgSO4) extracts
5. concentrationwere concentrated in vacuo
6. customto afford a solid
7. customRecrystallisation of the solid from ethyl acetate-methanol