Methyl iodide →

HRID 986069Notes

Reaction equation

HRID 986069 reaction equation
[Cl:1][C:2]1[C:3]([C:16]2[O:17][CH2:18][C:19]([CH3:22])([CH3:21])[N:20]=2)=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH3:23][I:24]>[N+](C)([O-])=O.CCOCC>[I-:24].[Cl:1][C:2]1[C:3]([CH2+:16]2[N:20]([CH3:23])[C:19]([CH3:22])([CH3:21])[CH2:18][O:17]2)=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 128028842-(3,5-Dichloro-4'-fluoro-2-[1,1'-biphenyl]yl)-4,4-dimethyl-2-oxazoline

Product 0

No Product data yet.

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6375NitromethaneSolvent

Procedure

A solution of 2-(3,5-dichloro-4'-fluoro-2-[1,1'-biphenyl]yl)-4,4-dimethyl-2-oxazoline (4.6 g, 13.6 mmol) and methyl iodide (7 ml) in nitromethane (30 ml) was stirred on a steam bath for sixteen hours. The cooled reaction mixture was diluted with dry ether (200 ml) and, after cooling in an ice-bath, the crystalline product was collected to give 6 g (92%) of the title compound, mp 214°-216° C. dec. Crystallization from acetonitrile-ether (1:3, v:v) provided an analytical sample of the title compound, mp 218°-219.5° C. dec.

Workup

  1. customThe cooled reaction mixture
  2. temperatureafter cooling in an ice-bath
  3. customthe crystalline product was collected

Sources & evidence

ORD record
ord-bb960b3e888e43f7a1e31eb6418aa173
Source dataset
uspto-grants-1987_12
Patent number
US04710513

Reaction notes

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