Acetone → HCID 178486123, compound

Participants

Reaction Steps

To a solution of 5.9 g (0.1 mole) of guanidine base and 30 ml of acetone a solution of 7.3 g (0.1 mole) of methyl isothiocyanate in 10 ml of acetone is added. The isothiocyanate solution is added at such a rate to the guanidine solution that the temperature of the mixture should not exceed 40° C. The reaction mixture is allowed to stand at 40° C. for 4 hours, whereupon the solvent is removed in vacuo. The residual light yellow oil is suspended in water to yield an opalescent solution. Carbon dioxide gas is introduced into the solution thus obtained and the desired compound precipitates in the form of white crystals.

Provenance & Evidence