Acetone → HCID 178486123, compound

HRID 986095Notes

Reaction equation

HRID 986095 reaction equation
N[C:2]([NH2:4])=[NH:3].[CH3:5][N:6]=[C:7]=[S:8].[N-:9]=C=S.[C:12](=[O:14])=[O:13].CC(C)=[O:17]>>[C:12](=[O:17])([OH:14])[OH:13].[NH2:9][N:3]=[CH:2][NH:4][C:7]([NH:6][CH3:5])=[S:8]

Participants

6

Reactant 5

HCID 180Acetone2×HCID 280Carbon DioxideHCID 3520Guanidine2×HCID 11167Methyl isothiocyanateHCID 178418790HCID 178418790, compound

Product 1

HCID 178486123HCID 178486123, compound

Procedure

To a solution of 5.9 g (0.1 mole) of guanidine base and 30 ml of acetone a solution of 7.3 g (0.1 mole) of methyl isothiocyanate in 10 ml of acetone is added. The isothiocyanate solution is added at such a rate to the guanidine solution that the temperature of the mixture should not exceed 40° C. The reaction mixture is allowed to stand at 40° C. for 4 hours, whereupon the solvent is removed in vacuo. The residual light yellow oil is suspended in water to yield an opalescent solution. Carbon dioxide gas is introduced into the solution thus obtained and the desired compound precipitates in the form of white crystals.

Workup

  1. customexceed 40° C
  2. customis removed in vacuo
  3. customto yield an opalescent solution
  4. customthus obtained
  5. customthe desired compound precipitates in the form of white crystals

Sources & evidence

ORD record
ord-fe76a3892d8e488f8ce616083d773efd
Source dataset
uspto-grants-1987_12
Patent number
US04710578

Reaction notes

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