反应详情

Metal sodium (0.33 gram) is dissolved in 40 ml of anhydrous isopropyl alcohol and the solution is heated to reflux for one hour with 2 grams of the 2-phenyl-4-quinolone-6-carboxylic acid obtained in Example 2. After cooling, the solution is mixed with ice water, acidified with acetic acid, the crystals which separate out therefrom are collected by filtration. The crystals are washed with water, washed with methanol, and dried to give 0.6 gram of isopropyl 2-phenyl-4-quinolone-6-carboxylate, colorless powder, melting at above 300° C.

1. temperaturethe solution is heated
2. temperatureAfter cooling
3. customthe crystals which separate out
4. filtrationtherefrom are collected by filtration
5. washThe crystals are washed with water
6. washwashed with methanol
7. customdried