HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 986241Generated: October 30, 2026
Dimethylformamide → Methyl 1-methyl-2-phenyl-4-quinolone-6-carboxylate
https://huagongshe.com/reaction/986241
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-phenyl-4-quinolone-6-carboxylate | HCID 70432662 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 1-methyl-2-phenyl-4-quinolone-6-carboxylate | HCID 13421599 | — |
Reaction Steps
A mixture of 2 grams of methyl 2-phenyl-4-quinolone-6-carboxylate (obtained in Example 1), 16 ml of methyl iodide, 2 grams of potassium carbonate and 50 ml of dimethyl formamide is stirred for four hours at 60° C. After cooling, the mixture is poured into water and extracted with ethyl acetate. From the extract ethylacetate is evaporated, the residue is purified by silica chromatography, and 1.8 grams of methyl 1-methyl-2-phenyl-4-quinolone-6-carboxylate, colorless powder, melting point 174° to 176° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04711898 |
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| Source dataset | uspto-grants-1987_12 |
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| ORD ID | ord-4a8fa1e9fabc41258468240755039bd9 |
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| Source note | uspto-grants-1987_12 |
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