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HRID986241

反应详情

EQUATION

反应方程式

HRID 986241 的结构方程式

REACTANTS

反应物

4
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CI
HCID6328

Methyl iodide

CH3I

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：COC(=O)c1ccc2c(c1)C(=O)CC(c1ccccc1)=N2
HCID70432662

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1ccc2c(c1)c(=O)cc(-c1ccccc1)n2C
HCID13421599

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

A mixture of 2 grams of methyl 2-phenyl-4-quinolone-6-carboxylate (obtained in Example 1), 16 ml of methyl iodide, 2 grams of potassium carbonate and 50 ml of dimethyl formamide is stirred for four hours at 60° C. After cooling, the mixture is poured into water and extracted with ethyl acetate. From the extract ethylacetate is evaporated, the residue is purified by silica chromatography, and 1.8 grams of methyl 1-methyl-2-phenyl-4-quinolone-6-carboxylate, colorless powder, melting point 174° to 176° C., is obtained.

WORKUP

后处理

  1. temperatureAfter cooling
  2. extractionextracted with ethyl acetate
  3. customFrom the extract ethylacetate is evaporated
  4. customthe residue is purified by silica chromatography, and 1.8 grams of methyl 1-methyl-2-phenyl-4-quinolone-6-carboxylate, colorless powder, melting point 174° to 176° C.
  5. customis obtained