Hydrochloric Acid → HCID 178468750, compound

HRID 986246Notes

Reaction equation

HRID 986246 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH2:17][C:16](=[O:18])[C:15]2[C:10](=[C:11]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:12]=[CH:13][CH:14]=2)[N:9]=1.Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:17]=[C:16]([OH:18])[C:15]2[C:10](=[C:11]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:12]=[CH:13][CH:14]=2)[N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70432832HCID 70432832, compound

Product 1

HCID 178468750HCID 178468750, compoundYield 172.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 2-(2-chlorophenyl)-4-quinolone-8-carboxylate (1.98 gram) is dissolved in 50 ml of methanol, and stirred at room temperature for 0.5 hour with 10 ml of 40% ethanolic hydrochloric acid. The solvent is evaporated from the solution, and the residue is recrystallized from ethanol to give 1.9 grams of ethyl 2-(2-chlorophenyl)-4-hydroxyquinoline-8-carboxylate hydrochloride, colorless prisms, melting point 196° to 198° C.

Workup

  1. customThe solvent is evaporated from the solution
  2. customthe residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-958b92daa27b4cb49a1fe3ab99a87dc1
Source dataset
uspto-grants-1987_12
Patent number
US04711898

Reaction notes

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