Potassium Carbonate → 1-(4-Benzoyloxyphenyl)-2-(4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-1-piperidyl)-1-propanone

Participants

Reaction Steps

A mixture of 10.99 g (0.04 mole) of 2-chloro-1-(4-benzyloxyphenyl)-1-propanone, 10.05 g (0.04 mole) of 2-(4-fluorophenyl)-2-(4-piperidyl)-1,3-dioxolane, 5.52 g of potassium carbonate and 150 ml of acetonitrile is heated under reflux for 4 h. Working as described in Example 4a, an oil is isolated which is used as it is in the following stage.

Provenance & Evidence