Potassium Carbonate → 1-(4-Benzoyloxyphenyl)-2-(4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-1-piperidyl)-1-propanone

HRID 986260Notes

Reaction equation

HRID 986260 reaction equation
Cl[CH:2]([CH3:19])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)=[O:4].[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2([CH:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)[O:31][CH2:30][CH2:29][O:28]2)=[CH:23][CH:22]=1.C(=O)([O-])[O-:39].[K+].[K+]>C(#N)C>[C:12]([O:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH:2]([N:35]2[CH2:36][CH2:37][CH:32]([C:27]3([C:24]4[CH:25]=[CH:26][C:21]([F:20])=[CH:22][CH:23]=4)[O:31][CH2:30][CH2:29][O:28]3)[CH2:33][CH2:34]2)[CH3:19])=[CH:6][CH:7]=1)(=[O:39])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 121191951-Propanone, 2-chloro-1-[4-(phenylmethoxy)phenyl]-HCID 132790992-(4-Fluorophenyl)-2-(4-piperidyl)1,3-dioxolane

Product 1

HCID 201584641-(4-Benzoyloxyphenyl)-2-(4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-1-piperidyl)-1-propanone

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 10.99 g (0.04 mole) of 2-chloro-1-(4-benzyloxyphenyl)-1-propanone, 10.05 g (0.04 mole) of 2-(4-fluorophenyl)-2-(4-piperidyl)-1,3-dioxolane, 5.52 g of potassium carbonate and 150 ml of acetonitrile is heated under reflux for 4 h. Working as described in Example 4a, an oil is isolated which is used as it is in the following stage.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 4 h
  3. customan oil is isolated which

Sources & evidence

ORD record
ord-1c29182998ff4e339a0187368c3842dd
Source dataset
uspto-grants-1987_12
Patent number
US04711899

Reaction notes

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