HRID986260

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID12119195

1-Propanone, 2-chloro-1-[4-(phenylmethoxy)phenyl]-

C16H15ClO2

HCID13279099

未命名化合物

PRODUCTS

生成物

结构：CC(C(=O)c1ccc(OC(=O)c2ccccc2)cc1)N1CCC(C2(c3ccc(F)cc3)OCCO2)CC1

HCID20158464

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A mixture of 10.99 g (0.04 mole) of 2-chloro-1-(4-benzyloxyphenyl)-1-propanone, 10.05 g (0.04 mole) of 2-(4-fluorophenyl)-2-(4-piperidyl)-1,3-dioxolane, 5.52 g of potassium carbonate and 150 ml of acetonitrile is heated under reflux for 4 h. Working as described in Example 4a, an oil is isolated which is used as it is in the following stage.

WORKUP

后处理

temperatureis heated
temperatureunder reflux for 4 h
customan oil is isolated which

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1c29182998ff4e339a0187368c3842dd
来源数据集: uspto-grants-1987_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04711899
来源说明: uspto-grants-1987_12

反应 SMILES

Cl[CH:2]([CH3:19])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)=[O:4].[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2([CH:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)[O:31][CH2:30][CH2:29][O:28]2)=[CH:23][CH:22]=1.C(=O)([O-])[O-:39].[K+].[K+]>C(#N)C>[C:12]([O:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH:2]([N:35]2[CH2:36][CH2:37][CH:32]([C:27]3([C:24]4[CH:25]=[CH:26][C:21]([F:20])=[CH:22][CH:23]=4)[O:31][CH2:30][CH2:29][O:28]3)[CH2:33][CH2:34]2)[CH3:19])=[CH:6][CH:7]=1)(=[O:39])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1