3'-Aminoacetophenone → 3'-Acetamidoacetophenone

HRID 986261Notes

Reaction equation

HRID 986261 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH2:8][C:9]1[CH:10]=[C:11]([C:15](=[O:17])[CH3:16])[CH:12]=[CH:13][CH:14]=1>C1(C)C=CC=CC=1>[C:1]([NH:8][C:9]1[CH:10]=[C:11]([C:15](=[O:17])[CH3:16])[CH:12]=[CH:13][CH:14]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 74173'-AminoacetophenoneHCID 7918Acetic Anhydride

Product 1

HCID 3462023'-Acetamidoacetophenone

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

50 ml of acetic anhydride are added in the cold to a suspension of 30 g (0.22 mole) of 1-(3-aminophenyl)ethanone in 200 ml of toluene, and the mixture is stirred for 1 h at room temperature, then heated for 1 h to 60° C. and left to stand overnight. The precipitate obtained is drained, ground in ether and dried.

Workup

  1. temperatureheated for 1 h to 60° C.
  2. waitleft
  3. waitto stand overnight
  4. customThe precipitate obtained
  5. dry with materialground in ether and dried

Sources & evidence

ORD record
ord-3b778f1cd77f4826ae9e52573306c1a6
Source dataset
uspto-grants-1987_12
Patent number
US04711899

Reaction notes

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