3-Methylpiperidine → HCID 13336377, compound

HRID 986277Notes

Reaction equation

HRID 986277 reaction equation
[C:1]1([C:7]2[N:16]=[C:15]([C:17]([O:19]CC)=O)[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:22][CH:23]1[CH2:28][CH2:27][CH2:26][NH:25][CH2:24]1.C([Li])CCC>CCCCCC.O1CCCC1>[CH3:22][CH:23]1[CH2:28][CH2:27][CH2:26][N:25]([C:17]([C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[N:16]=2)=[O:19])[CH2:24]1

Participants

6

Reactant 3

HCID 790813-MethylpiperidineHCID 20158356HCID 20158356, compoundHCID 178418339Butyllithium

Product 1

HCID 13336377HCID 13336377, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8058HexaneSolvent

Procedure

The procedure of Example 24 is followed using ethyl 2-phenylquinazoline-4-carboxylate (3 g), 3-methylpiperidine (3 ml), a 1.6M solution of butyllithium in hexane (15 ml) and tetrahydrofuran (20 ml) as the starting materials. After recrystallisation from isopropyl ether, 3-methyl-1-[(2-phenylquinazolin-4-yl)-carbonyl]piperidine (1 g), melting at 116° C., is obtained.

Workup

  1. customAfter recrystallisation from isopropyl ether, 3-methyl-1-[(2-phenylquinazolin-4-yl)-carbonyl]piperidine (1 g), melting at 116° C.
  2. customis obtained

Sources & evidence

ORD record
ord-9f82affbac3a49ba8b21df9d3d50c4f4
Source dataset
uspto-grants-1987_12
Patent number
US04711890

Reaction notes

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