反应详情

温度

0 °C

2-Phenylquinoline-4-carboxylic acid chloride hydrochloride (10.7 g) is added in portions over a period of 15 minutes, with stirring, to a solution of N-methylaniline (12.8 g) in methylene chloride (75 ml), cooled to 0° C. The mixture is stirred for 2 hours 30 minutes at 10° C. The solution obtained is washed with a 20% strength solution of acetic acid in water (120 ml). The acetic acid solution is extracted with methylene chloride (100 ml). The organic phases are combined, washed with water (3×100 ml), dried over magnesium sulphate and evaporated under reduced pressure.

1. customThe solution obtained
2. washis washed with a 20% strength solution of acetic acid in water (120 ml)
3. extractionThe acetic acid solution is extracted with methylene chloride (100 ml)
4. washwashed with water (3×100 ml)
5. dry with materialdried over magnesium sulphate
6. customevaporated under reduced pressure