反应详情

To a solution of 290 mg of the amide compound in 5 ml of methyl alcohol was added 1.0 ml of a 2N-hydrochloric acid, and the mixture was heated under reflux for 3 hours. The reaction mixture was evaporated under reduced pressure to obtain 206 mg of 4-[(2RS, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyryl]morpholine hydrochloride as a white powder.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hours
3. customThe reaction mixture was evaporated under reduced pressure