Hydrochloric Acid → 4-[(2RS, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyryl]morpholine hydrochloride

HRID 986365Notes

Reaction equation

HRID 986365 reaction equation
C(OC([NH:8][C@@H:9]([CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[CH:10]([OH:19])[C:11]([N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1)=[O:12])=O)(C)(C)C.[ClH:27]>CO>[ClH:27].[NH2:8][C@@H:9]([CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[CH:10]([OH:19])[C:11]([N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1)=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 867419274-[(2RS, 3S)-3-(tertbutoxycarbonyl)amino-4-cyclohexyl-2-hydroxybutyryl]morpholine

Product 1

HCID 867419284-[(2RS, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyryl]morpholine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 290 mg of the amide compound in 5 ml of methyl alcohol was added 1.0 ml of a 2N-hydrochloric acid, and the mixture was heated under reflux for 3 hours. The reaction mixture was evaporated under reduced pressure to obtain 206 mg of 4-[(2RS, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyryl]morpholine hydrochloride as a white powder.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. customThe reaction mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c8ebbfe4a24e4984b6da8a311b1e0fa5
Source dataset
uspto-grants-1987_12
Patent number
US04711958

Reaction notes

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