HCID 610131, compound → HCID 14031955, compound

HRID 986396Notes

Reaction equation

HRID 986396 reaction equation
[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([O-])=O.[C:10]1([CH:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)C=[N:18][CH2:17]2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:25]1([CH:16]2[C:10]3[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH:3]([CH2:2][C:1]([O:7][CH2:8][CH3:9])=[O:6])[NH:18][CH2:17]2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 610131HCID 610131, compoundHCID 3595298Propanedioic acid, monoethyl ester

Product 1

HCID 14031955HCID 14031955, compoundYield 98.7%

Conditions

Temperature
120 °C

Procedure

A mixture of 8.6 g (0.06 mole) of monoethyl malonate and 10.0 g (0.048 mole) of 3,4-dihydro-4-phenylisoquinoline was stirred in a preheated oil bath at 120° C. for 45 min to give 14.0 g (98.7%) of ethyl 1,2,3,4-tetrahydro-4-phenyl-1-isoquinolineacetate as a pale yellow syrup. The ester was used in the next step without further purification.

Sources & evidence

ORD record
ord-83f17af5602b440f81a7e26965b5b8d0
Source dataset
uspto-grants-1987_12
Patent number
US04713386

Reaction notes

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